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“What’s best practice for responsive layouts (grid, flex, multi-col, …)?” This implies one best practice—when CSS offers various valid layout options. Let’s not limit ourselves, or pressure to justify valid choices—or oversimplify CSS suggesting learning one option was enough.
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There’s also this irony: The question has never been about how to make a layout responsive. An unstyled document is liquid and therefore responsive from the start. Therefore, the question for frontend developers was always this: How NOT to make layouts UNresponsive 😬